What is an opiate receptor

Opioid receptor

Synonym: opiate receptor
English: opioid receptor

1 definition

Opioid receptors are primarily in the CNS, but also in many other tissues (for example in the intestine) occurring transmembrane receptors that belong to the family of endorphin receptors.

2 classification

Opioid receptors can be divided into 3 groups:

  • μ receptors (MOR): Stimulation of the µ-opioid receptors causes supraspinal analgesia, respiratory depression, miosis, bradycardia, hypothermia and euphoria. The antitussive effects and the spastic paralysis of the intestine, which are mediated by μ-receptors, are among the most common effects that can be achieved through the therapeutic administration of opiate derivatives (codeine, loperamide). Regular stimulation of the μ-receptors leads to the development of tolerance and dependence.
  • κ receptors (KOR): Stimulation causes spinal analgesia, sedation, also miosis and possibly also dysphoria
  • δ receptors (DOR): Irritation causes stress-induced and spinal analgesia as well as respiratory depression, hypotension, arousal and development of tolerance.

σ-receptors have a distinctly different molecular genetic and structural structure and do not belong to the opioid receptors. However, like many other drugs, opioids can also bind to you. In the event of irritation, circulatory stimulation and mydriasis occur. Tolerance and dysphoria or hallucinations occur.

Opioids differ in their clinical effects due to their different affinity for the individual receptor types.

3 antagonism

The effect of opium derivatives on their receptors can be reversed by administering opioid antagonists. Naloxone is used in particular as an antidote for opioid-related respiratory depression, while naltrexone and nalmefene are used to treat opioid abuse as well as to prevent relapse of alcohol addiction.

see main article:Opioid antagonist