What are the best treatments for septicemia
Management of Early Onset Neonatal Septicemia: Choosing the Optimal Antibacterial Regimen for Empirical Treatment
A prospective randomized two-group study on changing the drug regimen is being carried out in the EU intensive care units at the Tartu University Hospital and the Tallinn Children's Hospital. Initially all patients receiving empirical treatment for early separation in Tartu will be tried with penicillin / gentamicin and in Tallinn with ampicillin / gentamicin. When the other of the other subjects are recruited, Department The Safety Regime will be switched so that ampicillin is used in Tartu and penicillin is used in Tartu Tallinn. Individuals based on patient population and hospitalization rate, approximately 120-150 babies eligible for the study will be in each year. In all possible cases, there are pre-defined pre- and intranatal infection risk functional effects. The following of stay in the intensive care unit are the labor and rights rights of one of the people concerned to be respiratory related and vasoactive therapy, enteral and parenteral experience. Blood, alcohol and urine cultures are done by the routine of the ward safely before any rule of antibacterial treatment. For colonization studies, nasopharyngeal or tracheal and anal swabs are given from all newborns the study time at admission and two verbal swabs until perception from the intensive care unit or until the 60th day of treatment. A protocol is provided for microbiology examinations. The endpoints: The real endpoint is the eligibility of one of the antibacterial treatment of 72 hours. I am talking to knowledge experts on both wards the rights for the change in antibacterial treatment has been dealt with: 1. After causal or suspected meningitis or abdominal infection 2. Isolation of a resistant microorganism from a body part of the mother or infant for better empirical treatment regimen in babies with premature neonatal sepsis or septic shock 3. worsening of affected status with interests antibiotic treatment and merit / protection sepsis in newborns 4. suspected / indulgent delayed separate sepsis or nosocomial infection clinical / laboratory rights of an infection in the postnatal age of 72 hours or more) 5. others Rights in which the access physician considers a rights of the control regime Understanding - the understanding is in the case report of the patient report, the perception before 72 hours or in which the antibacterial therapy will switch for other than that The above rights are treated as medical malpractice. Secondary endpoints include: - Rate and etiology of early and earlier onset of sepsis in newborns, susceptibility pattern of the personal microorganisms - Affected persons and etiology of nosocomial sepsis, susceptibility pattern of the pathogen microorganisms - Death rate of 60 days - Duration of hospital stay in the intensive care unit - Duration of the artificial respiration - colonization patterns and susceptibility to colonizing rights empirical insect regime).
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