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Clotrimazole

3 out of 4 women suffer from vaginal thrush at least once. Often does not favor Poor, but rather excessive, hygiene leads to the outbreak of the fungal infection. The active ingredient clotrimazole helps against vaginal fungus, but also athlete's foot or bran fungus.

The antifungal agent clotrimazole

Clotrimazole is an over-the-counter drug that belongs to the group of antifungal drugs and more precisely to the subgroup of Azole antifungal drugs belongs.

It is used to treat various fungal infections and is characterized by its broad effectiveness against many forms of pathogenic fungi.

On the history of clotrimazole

Bayer AG developed the active ingredient clotrimazole in the 1960s. It came out in 1973 under the brand name Canesten® in Germany as a cream, solution and vaginal tablet. Due to the good tolerability, the prescription requirement was lifted after 4 years.

The active ingredient is available as:

  • Vaginal tablets
  • Vaginal uvula
  • solution

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Clotrimazole is an antifungal agent (med. Antimycotic) that can be used for a variety of diseases. This is not only due to the active ingredient, but also to its availability in a wide variety of dosage forms. There are creams, sprays, powders and liquid solutions with clotrimazole. For internal use z. B. with vaginal thrush, the active ingredient is even available as a suppository.

Areas of application of clotrimazole

The active substance clotrimazole is used to treat Fungal diseases on the skin and mucous membranes used. It works against three types of fungi that can cause skin fungal infections. This includes:

  • Dermatophytes
  • Yeasts, such as the Candida species
  • Molds

Clotrimazole also fights gram-positive bacteria and can therefore also be used against bacterial infections. Clotrimazole works against trichomonads (Trichomonas vaginalis - single-cell pathogens that can cause inflammation in the vagina and urethra).

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Clotrimazole is an all-rounder! The active ingredient not only has a containment effect with regard to the multiplication of fungi. He also works against Trichomonadsgram-positive bacteria that often cause vaginal infections. Not least for this reason, clotrimazole is ideal for treating vaginal yeast infections and bacterial vaginal infections. A combination treatment is usually carried out here. While the area of ​​the external genitals (vulva) is treated with a cream, the vagina is internally treated with suppositories.

The areas of application for clotrimazole therefore include:

The duration and exact dosage should be agreed with a doctor. Treatment with clotrimazole lasts an average of 2 to 4 weeks.

Our product tips for clotrimazole: Fungizid-ratiopharm® pump spray against athlete's foot | Mykohaug® C cream against skin fungus | Canifug® Cremolum® vaginal suppositories against vaginal thrush | CLOTRIMAZOL AL 200 vaginal tablets against vaginal thrush

How Clotrimazole Works

Clotrimazole is one of the Imidazole antifungal drugs. These antifungal agents work by preventing the fungus from growing. The active ingredient clotrimazole does this by preventing the formation of Ergosterol inhibits.

Ergosterol is an important building block for the cell membrane of the fungal cells. By preventing the build-up of ergosterol, clotrimazole ensures that the fungal cells can no longer multiply in a stable manner.

Clotrimazole works with it fungistaticas it fights the fungus by doing the Fungal growth disrupts. In addition, it disrupts the cell membrane of existing fungal cells by making them more impermeable to nutrients. The fungal cells starve to death after a while and then dissolve.

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There are fungicidal antifungal agents that kill existing fungi and fungistatic antifungal agents that prevent the fungi from multiplying further. Clotrimazole combines both functions. Depending on the concentration of the active ingredient, it achieves its effect in both ways. It inhibits the cell wall synthesis of the pathogens so that they can no longer multiply. In addition, it damages the cell wall of existing pathogen organisms, so that they die.

Contraindication of clotrimazole

If the patient is already allergic has reacted to clotrimazole, treatment with the active substance should be avoided.

During the pregnancy The use of clotrimazole for the treatment of vaginal yeast infections should definitely be discussed with a doctor. This is especially true for the first trimester of pregnancy, as studies show that there is an increased risk of miscarriage during this time. On the other hand, it is safe to use on the skin and does not harm the unborn child. The administration of vaginal tablets containing clotrimazole without an applicator is also possible during pregnancy.

During the Breastfeeding you should not use clotrimazole in the breast area to prevent it from being absorbed by the infant. A vaginal application, however, is possible on the instructions of the doctor.

Interactions of Clotrimazole

With the simultaneous use of clotrimazole and other antifungal agents with the active ingredients Amphotericin, nystatin, namatycin sometimes interactions occur. Clotrimazole may make these drugs less effective.

Therefore, inform your doctor or pharmacist if you use such drugs.

When used vaginally, clotrimazole may impair the effectiveness of condoms and diaphragms. In other words: the tear resistance and thus the safety of condoms is reduced by the use of creams and ointments containing clotrimazole.

When used externally, the areas of the skin should be free of cosmetics or deodorants. This also applies to means of intimate hygiene when used vaginally. Because these agents may reduce the effectiveness of clotrimazole.

Side effects of clotrimazole

Clotrimazole is a very well tolerated active ingredient. Occasionally, d. H. in 1 to 10 in 1000 patients, were given topical use Skin reactions how Redness, stinging, or burning sensation observed.

Instructions for use for clotrimazole

Pay attention to any age restrictions in the package insert. Some products containing clotrimazole should not be used by anyone under the age of 18.

If you use clotrimazole as a drip solution, please make sure that the agent does not get into your eyes.

Alternatives to clotrimazole

Clotrimazole is the treatment of choice for most skin fungal infections. It is available without a prescription and is very well tolerated by users. Alternative preparations are only available with a prescription. Talk to your doctor.


Our pages are for your information only and do not replace diagnosis and treatment by the doctor.

For information on risks and side effects, read the package insert and ask your doctor or pharmacist.

Despite careful research and the use of reliable sources, errors can sometimes creep into our texts. Help us improve. Send information to: [email protected]


As of: 20.10.2020

For reasons of better legibility, the male form is used in the text for personal designations. It goes without saying, however, that the information relates to members of both sexes.